Rash in chickenpox infection can be extremely itchy. Patients come with extreme itching on their arms, legs, face, and genitals. It is good to prescribe a calamine lotion to relieve their uneasiness. Patients are advised to keep their nails short and trimmed to prevent any further damage to the skin. Suppurative bacterial infection and subsequent pain and tenderness can occur in the affected area. Antibiotics are given to the patient in such circumstances.