It is one of the main symptoms in the cardiopulmonary phase of the disease. Blood pressure levels are usually dropped dramatically and the disease has a very rapid progression, sometimes leading patients to a severe cardiovascular compromise and shock. In cases of shock, the disease is life-threatening and requires urgent medical attention. It is associated with cardiovascular collapse, massive capillary leakage in the lungs, and other life-threatening complications. It is more common in fragile patients and those who already have a chronic cardiorespiratory condition.