10. Excessive fatigue
As liver damage increases, patients will also experience more constitutional symptoms, such as malaise and fatigue. The difference between tiredness and fatigue is that fatigue is a feeling of exhaustion and inability to engage in activities and is generally experienced as a persistent, unpleasant sensation of tiredness that does not go away quickly.
The symptom of fatigue can be experienced as a lack of physical energy or mental energy. The sensation does not go away after resting or sleeping all night. It happens either because the brain has accumulated ammonia and hepatic encephalopathy or because the liver has grown cancerous cells and the tumor consumes too much energy.