The thyroid is the major endocrine organ affected by lupus. Autoimmune thyroiditis is commonly seen in lupus patients. Both hyperthyroidism and hypothyroidism can occur in the patient depending on the course of the disease. It is reported that 6% of lupus patients suffer from hypothyroidism and 1% present with overactive thyroid gland resulting in hyperthyroidism. The thyroid is an important endocrine organ which controls the metabolism of the body, and its dysfunction can lead to devastating consequences on the patient’s health. Brain, heart, lung, kidney, and liver are likely to be affected when there is thyroid dysfunction. Hypothyroidism can cause dry skin, weight gain, muscle pain, depression, and other mood changes. Hyperthyroidism can cause heat intolerance, weight loss, cardiac arrhythmias, murmurs, and osteoporosis.