B) Environment triggered Rheumatoid Arthritis
It has been studied through years and years of research that environmentally triggered Rheumatoid Arthritis is due to the continuous activation of the innate immune system.
The biggest link between cigarette smoking and the development of Rheumatoid Arthritis comes from the theory that it induces the alveolar macrophages to convert a different amino acid; arginine into citrulline. This again triggers the immune response to form the ACPAs in the body, which starts by damaging the normal cells all over again.
