Reinfection can occur after the treatment of syphilis, so follow-up is required. Patients with early syphilis should be tested after 6 months and one year, and patients with latent syphilis should be tested after 6 months, one year and two years. Also, patients with HIV and syphilis should be tested after 3 months, 6 months, 9 months and one year. In the case of patients who didn’t receive penicillin as a first for treatment should be tested after 3 months, 6 months, 9 months and one year.
Patients with late syphilis should be tested for life, while patients with neurosyphilis should be tested each 6 months for 3 years. Pregnant females should routinely be tested for syphilis at the beginning of the infection, and pregnant females with syphilis should be tested each month until delivery.
Pregnant females who had fetal death after 20 weeks should be tested for syphilis. In high-risk communities, pregnant females should be tested once in the third trimester and once at delivery.
Homosexual individuals should be tested repeatedly, as reinfection is common among them. Patients with neurosyphilis should be tested for HIV as well.