Syphilis | Stages, Symptoms, Treatment & Prevention

B) Second stage (4 to 8 weeks after primary syphilis)

1- Skin rash

This is part of the secondary stage of symptoms. Skin rash is usually located in the palms of the hands and the soles of the feet, but it can also affect other parts of the body. It can last between 2 and 6 weeks per outbreak, and sometimes it is hard to notice because it is not usually itchy and may appear and disappear for a period of up to 2 years.