Multiple myeloma is associated with several neurologic symptoms and syndromes. One of the most important is carpal tunnel syndrome, which has a higher incidence in multiple myeloma patients than the average. This is because there’s excessive deposition of amyloid proteins in the carpal tunnel. These patients are also more susceptible to bacterial meningitis, usually due to a meningococcal or pneumococcal infection. These are typically late-stage problems, and their onset depends on how fast the disease is diagnosed and how accurate the treatment is.