10. Nervousness or agitation
There are many reasons why patients with migraines feel anxious or agitated. The prolonged headache symptoms are major contributors because the typical migraine headache lasts for 4 hours or more, and may even extend for more than one day. Moreover, pain triggers the sympathetic nervous system, which is specialized in the fight-or-flight response. This may also trigger the release of adrenaline to the bloodstream and lead to nervousness and agitation as a consequence.