10. Neurologic symptoms
Patients with leukemia and neurologic symptoms are often difficult to treat because they probably have a very severe condition called leukostasis. In these patients, there is an extremely high number of immature white blood cells in the blood, and this affects the normal circulation in the brain. This extra bulk in the blood slows down the normal circulation of the blood in the smaller arteries, leading to a reduction in oxygen and nutrients to the brain tissue. Leukostasis symptoms include an altered mental status, respiratory distress, seizures, and other neurologic problems.