8. Reduced appetite
Up to 20% of patients with leukemia experience early satiety and reduced appetite as a result of an increase of volume in the spleen. As it becomes bigger, the spleen fools the brain into thinking that the stomach is already full of food. It is something similar to what happens in bariatric surgery when a reduction of volume in the stomach results in lower energy intake and weight loss.
An additional reason contributing to a reduction of appetite is the role inflammatory cytokines have in the central nervous system. These and other inflammatory mediators released to the bloodstream inhibit appetite and may even result in vomiting or nausea after a large meal.